GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4038131 | 1 | rs62133586 | chr2:17806579 | GEN1 | chr2:17935162-17966632:+ | 0.6 | 7.03 | 7.16E-12 | Psychosis and Alzheimer's disease |
| THCA | cis | rs4038131 | 1 | rs62133587 | chr2:17806654 | GEN1 | chr2:17935162-17966632:+ | 0.6 | 7.03 | 7.16E-12 | Psychosis and Alzheimer's disease |
| THCA | cis | rs4038131 | 1 | rs62133588 | chr2:17807469 | GEN1 | chr2:17935162-17966632:+ | 0.6 | 7.03 | 7.16E-12 | Psychosis and Alzheimer's disease |
| THCA | cis | rs4038131 | 1 | rs62133589 | chr2:17807626 | GEN1 | chr2:17935162-17966632:+ | 0.6 | 7.03 | 7.16E-12 | Psychosis and Alzheimer's disease |
| THCA | cis | rs4038131 | 1 | rs62133590 | chr2:17811126 | GEN1 | chr2:17935162-17966632:+ | 0.63 | 7.2 | 2.42E-12 | Psychosis and Alzheimer's disease |
| THCA | cis | rs4853036 | 1 | rs62134006 | chr2:70050641 | SNRNP27 | chr2:70121090-70132348:+ | 0.17 | 4 | 7.29E-5 | Colorectal or endometrial cancer |
| THCA | cis | rs4853036 | 1 | rs62134009 | chr2:70054296 | SNRNP27 | chr2:70121090-70132348:+ | 0.18 | 4.12 | 4.41E-5 | Colorectal or endometrial cancer |
| THCA | cis | rs4802307 | 1 | rs62136099 | chr19:46847901 | PPP5C | chr19:46850294-46894103:+ | -0.24 | -4.29 | 2.13E-5 | Crohn's disease;Inflammatory bowel disease |
| THCA | cis | rs4802307 | 1 | rs62136101 | chr19:46854055 | PPP5C | chr19:46850294-46894103:+ | -0.23 | -3.92 | 9.99E-5 | Crohn's disease;Inflammatory bowel disease |
| THCA | cis | rs17818399 | 1 | rs62136864 | chr2:46829124 | ATP6V1E2 | chr2:46738988-46769696:- | -0.29 | -5.27 | 2.02E-7 | Height |
| THCA | cis | rs17818399 | 1 | rs62136864 | chr2:46829124 | CRIPT | chr2:46844325-46852880:+ | 0.24 | 4.43 | 1.14E-5 | Height |
| THCA | cis | rs17818399 | 1 | rs62136864 | chr2:46829124 | PIGF | chr2:46808414-46844251:- | 0.17 | 3.54 | 0.000447 | Height |
| THCA | cis | rs7573615 | 1 | rs62138361 | chr2:53225074 | CHAC2 | chr2:53994929-54002287:+ | 0.23 | 3.59 | 0.000363 | Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs7573615 | 1 | rs62138362 | chr2:53229061 | CHAC2 | chr2:53994929-54002287:+ | 0.23 | 3.53 | 0.000457 | Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs11125529 | 1 | rs62139200 | chr2:54475507 | C2orf73 | chr2:54558071-54588714:+ | 0.29 | 4.09 | 5.07E-5 | Telomere length |